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Artificial induction of immunity
Artificial induction of immunity is the artificial induction of immunity to specific diseases – making people immune to disease by means other than waiting for them to catch the disease. The purpose is to reduce the risk of death and suffering.〔
Immunity against infections that can cause serious illness is generally beneficial. Since Pasteur provided support for a germ theory of infectious disease, we have increasingly induced immunity against a widening range of diseases to prevent the associated risks from the wild infections.〔(【引用サイトリンク】url=http://www.unicef.org/immunization/ )〕 It is hoped that further understanding of the molecular basis of immunity will translate to improved clinical practice in the future.
== Variolation and smallpox ==
The earliest recorded artificial induction of immunity in humans was by variolation or inoculation, which is the controlled infection of a subject with a less lethal natural form of smallpox (known as Variola Minor) to make him or her immune to re-infection with the more lethal natural form, Variola Major. This was practiced in ancient times in China and India, and imported into Europe, via Turkey, around 1720 by Lady Montagu and perhaps others. From England, the technique spread rapidly to the Colonies, and was also spread by African slaves arriving into Boston.〔(【引用サイトリンク】National Institutes of Health ">work=Smallpox – A Great and Terrible Scourge )〕
Variolation had the disadvantage that the inoculating agent used was still an active form of smallpox and, although less potent, could still kill the inoculee or spread in its full form to others nearby. However, as the risk of death from inoculation with Variola Minor was just 1% to 2%, as compared to the 20% risk of death from the natural form of smallpox, the risks of inoculation were generally considered acceptable.〔〔Lettres Philosophiques. Voltaire.〕〔In fact, the mortality rate of the Varoiola Minor form of smallpox then found in Europe was 1–3% as opposed to 30–50% for the Variola Major type found elsewhere; however, blindness, infertility, and severe scarring were common. Figures from "The Search for Immunisation", In Our Time, BBC Radio 4 (2006).〕〔Letter of Lady Montagu reproduced at http://www.foundersofscience.net/lady_mary_montagu.htm viewed 18 March 2006〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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